MicroScope

MicroScope is an integrated Web platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis. It supports submissions of newly assembled genomes and metagenomes, and also provides analysis services for RNA-seq data. The user interface of MicroScope enables collaborative work in a rich comparative context to improve community-based curation efforts.

• Biomédical
• Agro-alimentaire
• Environnement
• Biotechnologie

L'équipe LABGeM du CEA/Genoscope a développé MicroScope, une plateforme web pour l'analyse des génomes procaryotes et l'annotation fonctionnelle experte. MicroScope combine des outils et des interfaces graphiques pour analyser les génomes dans un contexte comparatif et métabolique. Cette plateforme fournit des données provenant de milliers de projets sur le génome ainsi que des expériences post-génomiques permettant aux utilisateurs d'améliorer la compréhension des fonctions des gènes. Des annotations d'experts sont continuellement rassemblées dans la base de données MicroScope, ce qui contribue à l'amélioration de la qualité des annotations du génome microbien. MicroScope peut être utilisé comme une ressource communautaire pour l'analyse comparative et l'annotation des génomes accessibles au public, mais aussi comme une ressource privée avec des droits d'accès limités aux données génomiques.

• Methodology
• Metagenomics
• Metabolic Network Modelling
• Sequence Algorithm
• Machine learning
• Read alignment on genomes
• Gene expression differential analysis
• Web portals
• metatranscriptomics
• Variant analysis
• Interfaces
• System modeling
• Systems Biology
• Interoperability
• Genome analysis
• Knowledge mining
• Complete genomes
• Transcript and transcript variant analysis
• Transcriptomics (RNA-seq)
• Genomics (DNA-seq)
• Functional and regulatory pathways comparison
• Integration of heterogeneous data
• Knowledge representation
• Genomes comparison
• Data collection curation
• Comparative genomics
• Data Integration
• Data management and transfer
• NGS Sequencing Data Analysis
• Homology/orthology prediction
• Sequence annotation
• Pattern matching
• Multiple sequence alignment
• Toolkit
• Tool integration
• Workflow development
• Databases and information systems
• Développements technologiques de l‘Information et de la Communication

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.

Formations dédiées à l'analyse de génomes bactériens via l'utilisation de la plate-forme MicroScope.

Approfondissement des outils majeurs de la plateforme MicroScope

Annotation & Analysis Of Prokaryotic Genomes Using The MicroScope Platform

Annotation & Analysis Of Prokaryotic Genomes Using The MicroScope Platform

Annotation & Analysis Of Prokaryotic Genomes Using The MicroScope Platform

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.

In an effort to inform members of the research community about our annotation methods, to provide training for collaborators and other scientists who use the MicroScope platfom, and to inform scientific public on the analysis available in PkGDB (Prokaryotic Genome DataBase), we have developed a 4.5-day course in Microbial Genome Annotation and Comparative Analysis using the MaGe graphical interfaces.

This course will familiarize attendees with LABGeM’s annotation pipeline and the manual annotation software MaGe (Magnifying Genome) . No specific bioinformatics skill is required: detailed instruction on the algorithm developed in each annotation methods can be found in specific training courses on «Genomic sequences analysis». Here we focus on the general idea behind each method and, above all, the way you can interpret the corresponding results and combine them with other evidences in order to change or correct the current automatic functional annotation of a given gene, if necessary.

This course will also describe how to perform effective searches and analysis of procaryotic data using the graphical functionalities of the MaGe’s interfaces. Because of the numerous pre-computation available in our system (results of “common” annotation tools, synteny with all complete bacterial genomes, metabolic pathway reconstruction, fusion/fission events, genomic islands, …), many practical exercises allow attendees to get familiar with the use the MaGe graphical interfaces in order to efficiently explore these sets of results.