{"count":136,"next":"https://catalogue.france-bioinformatique.fr/api/topic/?format=json&limit=20&offset=60&ordering=description","previous":"https://catalogue.france-bioinformatique.fr/api/topic/?format=json&limit=20&offset=20&ordering=description","results":[{"id":111,"uri":"http://edamontology.org/topic_0121","label":"Proteomics","synonyms":["Peptide identification","Quantitative proteomics","MS-based targeted proteomics","Targeted proteomics","Metaproteomics","MS-based untargeted proteomics","Discovery proteomics","Top-down proteomics","Protein and peptide identification","Bottom-up proteomics"],"description":"Protein and peptide identification, especially in the study of whole proteomes of organisms."},{"id":24,"uri":"http://edamontology.org/topic_0128","label":"Protein interactions","synonyms":["Protein interaction networks","Protein-ligand interactions","Protein-nucleic acid interactions","Protein-DNA interactions","Protein-DNA interaction","Protein interaction map","Protein-RNA interaction","Protein-RNA interactions","Protein interactome","Protein-protein interactions"],"description":"Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions."},{"id":113,"uri":"http://edamontology.org/topic_2814","label":"Protein structure analysis","synonyms":["Protein tertiary structure","Protein structure"],"description":"Protein secondary or tertiary structural data and/or associated annotation."},{"id":65,"uri":"http://edamontology.org/topic_0749","label":"Transcription factors and regulatory sites","synonyms":["Attenuators","Transcription factors","GC signals","Terminators","-10 signals","TFBS","Isochores","-35 signals","Promoters","Enhancers","Transcriptional regulatory sites","TATA signals","CCAAT box","Transcription factor binding sites","CAAT signals","CAT box","CpG islands"],"description":"Proteins that bind to DNA and control transcription of DNA to mRNA (transcription factors) and also transcriptional regulatory sites, elements and regions (such as promoters, enhancers, silencers and boundary elements / insulators) in nucleotide sequences."},{"id":99,"uri":"http://edamontology.org/topic_0736","label":"Protein folds and structural domains","synonyms":["Protein domains","Protein membrane regions","Protein folds","Protein transmembrane regions","Protein topological domains","Protein structural domains","Intramembrane regions","Transmembrane regions"],"description":"Protein tertiary structural domains and folds in a protein or polypeptide chain."},{"id":106,"uri":"http://edamontology.org/topic_3520","label":"Proteomics experiment","synonyms":["2D PAGE experiment","Spectrum demultiplexing","Mass spectrometry experiments","MS","Northern blot experiment","MS experiments","DIA","Mass spectrometry","Data-independent acquisition"],"description":"Proteomics experiments."},{"id":18,"uri":"http://edamontology.org/topic_0092","label":"Data visualisation","synonyms":["Data rendering"],"description":"Rendering (drawing on a computer screen) or visualisation of molecular sequences, structures or other biomolecular data."},{"id":108,"uri":"http://edamontology.org/topic_3523","label":"RNAi experiment","synonyms":null,"description":"RNAi experiments."},{"id":118,"uri":"http://edamontology.org/topic_0099","label":"RNA","synonyms":["Small RNA"],"description":"RNA sequences and structures."},{"id":92,"uri":"http://edamontology.org/topic_3320","label":"RNA splicing","synonyms":["Alternative splicing","Splice sites"],"description":"RNA splicing; post-transcription RNA modification involving the removal of introns and joining of exons."},{"id":116,"uri":"http://edamontology.org/topic_3542","label":"Protein secondary structure","synonyms":["Protein super-secondary structure","Protein features (secondary structure)"],"description":"Secondary structure (predicted or real) of a protein, including super-secondary structure."},{"id":20,"uri":"http://edamontology.org/topic_0154","label":"Small molecules","synonyms":["Peptides and amino acids","Toxins and targets","Drugs and target structures","Drug targets","Peptides","Drug structures","Metabolite structures","Amino acids","Toxins","Targets","Chemical structures","Target structures"],"description":"Small molecules of biological significance, typically archival, curation, processing and analysis of structural information."},{"id":93,"uri":"http://edamontology.org/topic_0199","label":"Genetic variation","synonyms":["DNA variation","Somatic mutations","Genomic variation","Mutation","Polymorphism"],"description":"Stable, naturally occuring mutations in a nucleotide sequence including alleles, naturally occurring mutations such as single base nucleotide substitutions, deletions and insertions, RFLPs and other polymorphisms."},{"id":115,"uri":"http://edamontology.org/topic_0166","label":"Protein structural motifs and surfaces","synonyms":["Protein surfaces","Protein structural features","Protein 3D motifs","Structural motifs","Protein structural motifs"],"description":"Structural features or common 3D motifs within protein structures, including the surface of a protein structure, such as biological interfaces with other molecules."},{"id":90,"uri":"http://edamontology.org/topic_0781","label":"Virology","synonyms":null,"description":"Study of viruses, e.g. sequence and structural data, interactions of viral proteins, or a viral genome including molecular sequences, genes and annotation."},{"id":8,"uri":"http://edamontology.org/topic_3077","label":"Data acquisition","synonyms":["Data collection"],"description":"The acquisition of data, typically measurements of physical systems using any type of sampling system, or by another other means."},{"id":27,"uri":"http://edamontology.org/topic_0203","label":"Gene expression","synonyms":["DNA chips","DNA microarrays","Gene translation","Transcription","Expression","Gene expression profiling","Codon usage","Gene transcription"],"description":"The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."},{"id":105,"uri":"http://edamontology.org/topic_3169","label":"ChIP-seq","synonyms":["ChIP-sequencing","Chip sequencing","Chip Seq","ChIP-exo","Chip-sequencing"],"description":"The analysis of protein-DNA interactions where chromatin immunoprecipitation (ChIP) is used in combination with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins."},{"id":51,"uri":"http://edamontology.org/topic_3308","label":"Transcriptomics","synonyms":["Transcriptome","Comparative transcriptomics","Metatranscriptomics"],"description":"The analysis of transcriptomes, or a set of all the RNA molecules in a specific cell, tissue etc."},{"id":61,"uri":"http://edamontology.org/topic_3063","label":"Medical informatics","synonyms":["Biomedical informatics","Health and disease","Clinical informatics","Healthcare informatics","Health informatics"],"description":"The application of information technology to health, disease and biomedicine."}]}