{"count":136,"next":"https://catalogue.france-bioinformatique.fr/api/topic/?format=json&limit=20&offset=40&ordering=uri","previous":"https://catalogue.france-bioinformatique.fr/api/topic/?format=json&limit=20&ordering=uri","results":[{"id":31,"uri":"http://edamontology.org/topic_0176","label":"Molecular dynamics","synonyms":["Protein dynamics"],"description":"The study and simulation of molecular (typically protein) conformation using a computational model of physical forces and computer simulation."},{"id":68,"uri":"http://edamontology.org/topic_0194","label":"Phylogenomics","synonyms":null,"description":"The integrated study of evolutionary relationships and whole genome data, for example, in the analysis of species trees, horizontal gene transfer and evolutionary reconstruction."},{"id":22,"uri":"http://edamontology.org/topic_0196","label":"Sequence assembly","synonyms":["Assembly"],"description":"The assembly of fragments of a DNA sequence to reconstruct the original sequence."},{"id":93,"uri":"http://edamontology.org/topic_0199","label":"Genetic variation","synonyms":["DNA variation","Somatic mutations","Genomic variation","Mutation","Polymorphism"],"description":"Stable, naturally occuring mutations in a nucleotide sequence including alleles, naturally occurring mutations such as single base nucleotide substitutions, deletions and insertions, RFLPs and other polymorphisms."},{"id":27,"uri":"http://edamontology.org/topic_0203","label":"Gene expression","synonyms":["DNA chips","DNA microarrays","Gene translation","Transcription","Expression","Gene expression profiling","Codon usage","Gene transcription"],"description":"The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."},{"id":73,"uri":"http://edamontology.org/topic_0204","label":"Gene regulation","synonyms":["Regulatory genomics"],"description":"The regulation of gene expression."},{"id":78,"uri":"http://edamontology.org/topic_0219","label":"Data submission, annotation and curation","synonyms":["Database curation","Data curation","Data provenance"],"description":"Deposition and curation of database accessions, including annotation, typically with terms from a controlled vocabulary."},{"id":32,"uri":"http://edamontology.org/topic_0593","label":"NMR","synonyms":["Nuclear Overhauser Effect Spectroscopy","Rotational Frame Nuclear Overhauser Effect Spectroscopy","ROESY","Nuclear magnetic resonance spectroscopy","NOESY","NMR spectroscopy","Heteronuclear Overhauser Effect Spectroscopy","HOESY"],"description":"An analytical technique that exploits the magenetic properties of certain atomic nuclei to provide information on the structure, dynamics, reaction state and chemical environment of molecules."},{"id":77,"uri":"http://edamontology.org/topic_0602","label":"Molecular interactions, pathways and networks","synonyms":["Networks","Gene regulatory networks","Interactome","Molecular interactions","Disease pathways","Biological pathways","Signaling pathways","Pathways","Environmental information processing pathways","Cellular process pathways","Genetic information processing pathways","Signal transduction pathways","Biological models","Metabolic pathways","Biological networks","Interactions"],"description":"Molecular interactions, biological pathways, networks and other models."},{"id":17,"uri":"http://edamontology.org/topic_0605","label":"Informatics","synonyms":["Information science","Knowledge management","Information management"],"description":"The study and practice of information processing and use of computer information systems."},{"id":85,"uri":"http://edamontology.org/topic_0610","label":"Ecology","synonyms":["Ecological informatics","Ecoinformatics","Ecosystem science","Computational ecology"],"description":"The ecological and environmental sciences and especially the application of information technology (ecoinformatics)."},{"id":80,"uri":"http://edamontology.org/topic_0621","label":"Model organisms","synonyms":["Organisms"],"description":"A specific organism, or group of organisms, used to study a particular aspect of biology."},{"id":72,"uri":"http://edamontology.org/topic_0622","label":"Genomics","synonyms":["Exomes","Synthetic genomics","Genome annotation","Whole genomes","Personal genomics","Genomes","Viral genomics"],"description":"Whole genomes of one or more organisms, or genomes in general, such as meta-information on genomes, genome projects, gene names etc."},{"id":70,"uri":"http://edamontology.org/topic_0623","label":"Gene and protein families","synonyms":["Gene system","Gene families","Gene family","Protein sequence classification","Protein families","Genes, gene family or system"],"description":"Particular gene(s), gene family or other gene group or system and their encoded proteins.Primarily the classification of proteins (from sequence or structural data) into clusters, groups, families etc., curation of a particular protein or protein family, or any other proteins that have been classified as members of a common group."},{"id":62,"uri":"http://edamontology.org/topic_0625","label":"Genotype and phenotype","synonyms":["Phenotype","Genotyping","Genotype-phenotype analysis","Phenotyping","Genotype","Genotype and phenotype resources","Genotype-phenotype"],"description":"The study of genetic constitution of a living entity, such as an individual, and organism, a cell and so on, typically with respect to a particular observable phenotypic traits, or resources concerning such traits, which might be an aspect of biochemistry, physiology, morphology, anatomy, development and so on."},{"id":97,"uri":"http://edamontology.org/topic_0632","label":"Probes and primers","synonyms":["Primers","Primer quality","Probes"],"description":"Molecular probes (e.g. a peptide probe or DNA microarray probe) or PCR primers and hybridisation oligos in a nucleic acid sequence."},{"id":96,"uri":"http://edamontology.org/topic_0634","label":"Pathology","synonyms":["Pathology","Disease"],"description":"Diseases, including diseases in general and the genes, gene variations and proteins involved in one or more specific diseases."},{"id":9,"uri":"http://edamontology.org/topic_0637","label":"Taxonomy","synonyms":null,"description":"Organism classification, identification and naming."},{"id":40,"uri":"http://edamontology.org/topic_0654","label":"DNA","synonyms":["Ancient DNA","DNA analysis","Chromosomes"],"description":"DNA sequences and structure, including processes such as methylation and replication."},{"id":103,"uri":"http://edamontology.org/topic_0659","label":"Functional, regulatory and non-coding RNA","synonyms":["lncRNA","Small ncRNA","Small interfering RNA","Small nuclear RNA","siRNA","ncRNA","snRNA","snoRNA","Long non-coding RNA","Functional RNA","piwi-interacting RNA","piRNA","Long ncRNA","microRNA","miRNA","Small nucleolar RNA","Small and long non-coding RNAs","Non-coding RNA","Small non-coding RNA","Regulatory RNA"],"description":"Non-coding or functional RNA sequences, including regulatory RNA sequences, ribosomal RNA (rRNA) and transfer RNA (tRNA)."}]}