{"count":136,"next":"https://catalogue.france-bioinformatique.fr/api/topic/?format=json&limit=20&offset=120","previous":"https://catalogue.france-bioinformatique.fr/api/topic/?format=json&limit=20&offset=80","results":[{"id":74,"uri":"http://edamontology.org/topic_0078","label":"Proteins","synonyms":["Protein informatics","Protein bioinformatics","Protein databases"],"description":"Archival, processing and analysis of protein data, typically molecular sequence and structural data."},{"id":62,"uri":"http://edamontology.org/topic_0625","label":"Genotype and phenotype","synonyms":["Phenotype","Genotyping","Genotype-phenotype analysis","Phenotyping","Genotype","Genotype and phenotype resources","Genotype-phenotype"],"description":"The study of genetic constitution of a living entity, such as an individual, and organism, a cell and so on, typically with respect to a particular observable phenotypic traits, or resources concerning such traits, which might be an aspect of biochemistry, physiology, morphology, anatomy, development and so on."},{"id":22,"uri":"http://edamontology.org/topic_0196","label":"Sequence assembly","synonyms":["Assembly"],"description":"The assembly of fragments of a DNA sequence to reconstruct the original sequence."},{"id":23,"uri":"http://edamontology.org/topic_3168","label":"Sequencing","synonyms":["Panels","Primer walking","DNA-Seq","High-throughput sequencing","Chromosome walking","Next generation sequencing","NGS data analysis","Next gen sequencing","High throughput sequencing","Targeted next-generation sequencing panels","NGS","Sanger sequencing","Clone verification","DNase-Seq"],"description":"The determination of complete (typically nucleotide) sequences, including those of genomes (full genome sequencing, de novo sequencing and resequencing), amplicons and transcriptomes."},{"id":96,"uri":"http://edamontology.org/topic_0634","label":"Pathology","synonyms":["Pathology","Disease"],"description":"Diseases, including diseases in general 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structural domains and folds in a protein or polypeptide chain."},{"id":63,"uri":"http://edamontology.org/topic_3053","label":"Genetics","synonyms":["Genes","Heredity"],"description":"The study of genes, genetic variation and heredity in living organisms."},{"id":104,"uri":"http://edamontology.org/topic_0082","label":"Structure prediction","synonyms":["Nucleic acid design","Nucleic acid folding","RNA structure prediction","Protein structure prediction","Nucleic acid structure prediction","DNA structure prediction","Protein fold recognition"],"description":"The prediction of molecular structure, including the prediction, modelling, recognition or design of protein secondary or tertiary structure or other structural features, and the folding of nucleic acid molecules and the prediction or design of nucleic acid (typically RNA) sequences with specific conformations."},{"id":75,"uri":"http://edamontology.org/topic_3307","label":"Computational biology","synonyms":["Mathematical biology","Biomathematics","Theoretical biology"],"description":"The development and application of theory, analytical methods, mathematical models and computational simulation of biological systems."},{"id":61,"uri":"http://edamontology.org/topic_3063","label":"Medical informatics","synonyms":["Biomedical informatics","Health and disease","Clinical informatics","Healthcare informatics","Health informatics"],"description":"The application of information technology to health, disease and biomedicine."},{"id":93,"uri":"http://edamontology.org/topic_0199","label":"Genetic variation","synonyms":["DNA variation","Somatic mutations","Genomic variation","Mutation","Polymorphism"],"description":"Stable, naturally occuring mutations in a nucleotide sequence including alleles, naturally occurring mutations such as single base nucleotide substitutions, deletions and insertions, RFLPs and other polymorphisms."},{"id":91,"uri":"http://edamontology.org/topic_3324","label":"Infectious disease","synonyms":["Transmissable disease","Communicable disease"],"description":"The branch of medicine that deals with the prevention, diagnosis and management of transmissable disease with clinically evident illness resulting from infection with pathogenic biological agents (viruses, bacteria, fungi, protozoa, parasites and prions)."},{"id":89,"uri":"http://edamontology.org/topic_3957","label":"Protein interaction experiment","synonyms":["Phage display","Yeast one-hybrid","Co-immunoprecipitation","Yeast two-hybrid"],"description":"An experiment for studying protein-protein interactions."},{"id":64,"uri":"http://edamontology.org/topic_3172","label":"Metabolomics","synonyms":["Exometabolomics","Metabolites","Metabonomics","MS-based metabolomics","MS-based untargeted metabolomics","NMR-based metabolomics","Metabolome","LC-MS-based metabolomics","MS-based targeted metabolomics","Mass spectrometry-based metabolomics"],"description":"The systematic study of metabolites, the chemical processes they are involved, and the chemical fingerprints of specific cellular processes in a whole cell, tissue, organ or organism."},{"id":58,"uri":"http://edamontology.org/topic_2229","label":"Cell biology","synonyms":["Protein subcellular localization","Cellular processes","Cells"],"description":"Cells, such as key genes and proteins involved in the cell cycle."},{"id":32,"uri":"http://edamontology.org/topic_0593","label":"NMR","synonyms":["Nuclear Overhauser Effect Spectroscopy","Rotational Frame Nuclear Overhauser Effect Spectroscopy","ROESY","Nuclear magnetic resonance spectroscopy","NOESY","NMR spectroscopy","Heteronuclear Overhauser Effect Spectroscopy","HOESY"],"description":"An analytical technique that exploits the magenetic properties of certain atomic nuclei to provide information on the structure, dynamics, reaction state and chemical environment of molecules."},{"id":79,"uri":"http://edamontology.org/topic_2259","label":"Systems biology","synonyms":["Biological system modelling","Systems modelling","Biological modelling"],"description":"The holistic modelling and analysis of complex biological systems and the interactions therein."}]}