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{
"count": 127,
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{
"id": 10,
"uri": "http://edamontology.org/topic_0077",
"label": "Nucleic acids",
"synonyms": [
"Nucleic acid properties",
"Nucleic acid physicochemistry",
"Nucleic acid informatics",
"Nucleic acid bioinformatics"
],
"description": "The processing and analysis of nucleic acid sequence, structural and other data."
},
{
"id": 74,
"uri": "http://edamontology.org/topic_0078",
"label": "Proteins",
"synonyms": [
"Protein informatics",
"Protein bioinformatics",
"Protein databases"
],
"description": "Archival, processing and analysis of protein data, typically molecular sequence and structural data."
},
{
"id": 38,
"uri": "http://edamontology.org/topic_0080",
"label": "Sequence analysis",
"synonyms": [
"Sequences",
"Biological sequences",
"Sequence databases"
],
"description": "The archival, processing and analysis of molecular sequences (monomer composition of polymers) including molecular sequence data resources, sequence sites, alignments, motifs and profiles."
},
{
"id": 28,
"uri": "http://edamontology.org/topic_0081",
"label": "Structure analysis",
"synonyms": [
"Structural bioinformatics",
"Computational structural biology",
"Structure data resources",
"Molecular structure",
"Structures",
"Structure databases",
"Biomolecular structure"
],
"description": "The curation, processing, analysis and prediction of data about the structure of biological molecules, typically proteins and nucleic acids and other macromolecules."
},
{
"id": 104,
"uri": "http://edamontology.org/topic_0082",
"label": "Structure prediction",
"synonyms": [
"Nucleic acid design",
"Nucleic acid folding",
"RNA structure prediction",
"Protein structure prediction",
"Nucleic acid structure prediction",
"DNA structure prediction",
"Protein fold recognition"
],
"description": "The prediction of molecular structure, including the prediction, modelling, recognition or design of protein secondary or tertiary structure or other structural features, and the folding of nucleic acid molecules and the prediction or design of nucleic acid (typically RNA) sequences with specific conformations."
},
{
"id": 56,
"uri": "http://edamontology.org/topic_0084",
"label": "Phylogeny",
"synonyms": [
"Phylogenetic simulation",
"Phylogenetic clocks",
"Phylogeny reconstruction",
"Phylogenetic stratigraphy",
"Phylogenetic dating"
],
"description": "The study of evolutionary relationships amongst organisms."
},
{
"id": 82,
"uri": "http://edamontology.org/topic_0085",
"label": "Functional genomics",
"synonyms": null,
"description": "The study of gene or protein functions and their interactions in totality in a given organism, tissue, cell etc."
},
{
"id": 55,
"uri": "http://edamontology.org/topic_0089",
"label": "Ontology and terminology",
"synonyms": [
"Upper ontology",
"Terminology",
"Ontology",
"Ontologies",
"Ontology relations",
"Applied ontology"
],
"description": "The conceptualisation, categorisation and nomenclature (naming) of entities or phenomena within biology or bioinformatics. This includes formal ontologies, controlled vocabularies, structured glossary, symbols and terminology or other related resource."
},
{
"id": 88,
"uri": "http://edamontology.org/topic_0091",
"label": "Bioinformatics",
"synonyms": null,
"description": "The archival, curation, processing and analysis of complex biological data."
},
{
"id": 18,
"uri": "http://edamontology.org/topic_0092",
"label": "Data visualisation",
"synonyms": [
"Data rendering"
],
"description": "Rendering (drawing on a computer screen) or visualisation of molecular sequences, structures or other biomolecular data."
},
{
"id": 39,
"uri": "http://edamontology.org/topic_0097",
"label": "Nucleic acid structure analysis",
"synonyms": [
"DNA structure",
"Nucleic acid structure",
"Nucleic acid denaturation",
"DNA melting",
"RNA structure alignment",
"RNA structure",
"Nucleic acid thermodynamics",
"RNA alignment"
],
"description": "The archival, curation, processing and analysis of nucleic acid structural information, such as whole structures, structural features and alignments, and associated annotation."
},
{
"id": 118,
"uri": "http://edamontology.org/topic_0099",
"label": "RNA",
"synonyms": [
"Small RNA"
],
"description": "RNA sequences and structures."
},
{
"id": 12,
"uri": "http://edamontology.org/topic_0102",
"label": "Mapping",
"synonyms": [
"Linkage",
"Synteny",
"Genetic linkage",
"Linkage mapping"
],
"description": "The mapping of complete (typically nucleotide) sequences. Mapping (in the sense of short read alignment, or more generally, just alignment) has application in RNA-Seq analysis (mapping of transcriptomics reads), variant discovery (e.g. mapping of exome capture), and re-sequencing (mapping of WGS reads)."
},
{
"id": 117,
"uri": "http://edamontology.org/topic_0114",
"label": "Gene structure",
"synonyms": [
"Fusion genes",
"Gene features"
],
"description": "Gene structure, regions which make an RNA product and features such as promoters, coding regions, gene fusion, splice sites etc."
},
{
"id": 111,
"uri": "http://edamontology.org/topic_0121",
"label": "Proteomics",
"synonyms": [
"Peptide identification",
"Quantitative proteomics",
"MS-based targeted proteomics",
"Targeted proteomics",
"Metaproteomics",
"MS-based untargeted proteomics",
"Discovery proteomics",
"Top-down proteomics",
"Protein and peptide identification",
"Bottom-up proteomics"
],
"description": "Protein and peptide identification, especially in the study of whole proteomes of organisms."
},
{
"id": 24,
"uri": "http://edamontology.org/topic_0128",
"label": "Protein interactions",
"synonyms": [
"Protein interaction networks",
"Protein-ligand interactions",
"Protein-nucleic acid interactions",
"Protein-DNA interactions",
"Protein-DNA interaction",
"Protein interaction map",
"Protein-RNA interaction",
"Protein-RNA interactions",
"Protein interactome",
"Protein-protein interactions"
],
"description": "Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions."
},
{
"id": 20,
"uri": "http://edamontology.org/topic_0154",
"label": "Small molecules",
"synonyms": [
"Peptides and amino acids",
"Toxins and targets",
"Drugs and target structures",
"Drug targets",
"Peptides",
"Drug structures",
"Metabolite structures",
"Amino acids",
"Toxins",
"Targets",
"Chemical structures",
"Target structures"
],
"description": "Small molecules of biological significance, typically archival, curation, processing and analysis of structural information."
},
{
"id": 41,
"uri": "http://edamontology.org/topic_0157",
"label": "Sequence composition, complexity and repeats",
"synonyms": [
"Protein sequence repeats",
"Sequence complexity",
"Low complexity sequences",
"Nucleic acid repeats",
"Repeat sequences",
"Sequence composition",
"Sequence repeats",
"Protein repeats"
],
"description": "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences."
},
{
"id": 35,
"uri": "http://edamontology.org/topic_0160",
"label": "Sequence sites, features and motifs",
"synonyms": [
"Sequence profiles",
"Sequence sites",
"Sequence motifs",
"HMMs",
"Functional sites",
"Sequence features"
],
"description": "The archival, detection, prediction and analysis of positional features such as functional and other key sites, in molecular sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 115,
"uri": "http://edamontology.org/topic_0166",
"label": "Protein structural motifs and surfaces",
"synonyms": [
"Protein surfaces",
"Protein structural features",
"Protein 3D motifs",
"Structural motifs",
"Protein structural motifs"
],
"description": "Structural features or common 3D motifs within protein structures, including the surface of a protein structure, such as biological interfaces with other molecules."
}
]
}