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{
"id": 97,
"uri": "http://edamontology.org/topic_0632",
"label": "Probes and primers",
"synonyms": [
"Primers",
"Primer quality",
"Probes"
],
"description": "Molecular probes (e.g. a peptide probe or DNA microarray probe) or PCR primers and hybridisation oligos in a nucleic acid sequence."
},
{
"id": 99,
"uri": "http://edamontology.org/topic_0736",
"label": "Protein folds and structural domains",
"synonyms": [
"Protein domains",
"Protein membrane regions",
"Protein folds",
"Protein transmembrane regions",
"Protein topological domains",
"Protein structural domains",
"Intramembrane regions",
"Transmembrane regions"
],
"description": "Protein tertiary structural domains and folds in a protein or polypeptide chain."
},
{
"id": 31,
"uri": "http://edamontology.org/topic_0176",
"label": "Molecular dynamics",
"synonyms": [
"Protein dynamics"
],
"description": "The study and simulation of molecular (typically protein) conformation using a computational model of physical forces and computer simulation."
},
{
"id": 114,
"uri": "http://edamontology.org/topic_1775",
"label": "Function analysis",
"synonyms": [
"Protein function analysis",
"Protein function prediction",
"Functional analysis"
],
"description": "The study of gene and protein function including the prediction of functional properties of a protein."
},
{
"id": 74,
"uri": "http://edamontology.org/topic_0078",
"label": "Proteins",
"synonyms": [
"Protein informatics",
"Protein bioinformatics",
"Protein databases"
],
"description": "Archival, processing and analysis of protein data, typically molecular sequence and structural data."
},
{
"id": 24,
"uri": "http://edamontology.org/topic_0128",
"label": "Protein interactions",
"synonyms": [
"Protein interaction networks",
"Protein-ligand interactions",
"Protein-nucleic acid interactions",
"Protein-DNA interactions",
"Protein-DNA interaction",
"Protein interaction map",
"Protein-RNA interaction",
"Protein-RNA interactions",
"Protein interactome",
"Protein-protein interactions"
],
"description": "Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions."
},
{
"id": 19,
"uri": "http://edamontology.org/topic_3534",
"label": "Protein binding sites",
"synonyms": [
"Protein key folding sites",
"Protein cleavage sites",
"Enzyme active site",
"Protein-nucleic acid binding sites",
"Protein functional sites"
],
"description": "Binding sites in proteins, including cleavage sites (for a proteolytic enzyme or agent), key residues involved in protein folding, catalytic residues (active site) of an enzyme, ligand-binding (non-catalytic) residues of a protein, such as sites that bind metal, prosthetic groups or lipids, RNA and DNA-binding proteins and binding sites etc."
},
{
"id": 50,
"uri": "http://edamontology.org/topic_3510",
"label": "Protein sites, features and motifs",
"synonyms": [
"Protein sequence features",
"Signal peptide cleavage sites"
],
"description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in protein sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 41,
"uri": "http://edamontology.org/topic_0157",
"label": "Sequence composition, complexity and repeats",
"synonyms": [
"Protein sequence repeats",
"Sequence complexity",
"Low complexity sequences",
"Nucleic acid repeats",
"Repeat sequences",
"Sequence composition",
"Sequence repeats",
"Protein repeats"
],
"description": "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences."
},
{
"id": 58,
"uri": "http://edamontology.org/topic_2229",
"label": "Cell biology",
"synonyms": [
"Protein subcellular localization",
"Cellular processes",
"Cells"
],
"description": "Cells, such as key genes and proteins involved in the cell cycle."
},
{
"id": 116,
"uri": "http://edamontology.org/topic_3542",
"label": "Protein secondary structure",
"synonyms": [
"Protein super-secondary structure",
"Protein features (secondary structure)"
],
"description": "Secondary structure (predicted or real) of a protein, including super-secondary structure."
},
{
"id": 115,
"uri": "http://edamontology.org/topic_0166",
"label": "Protein structural motifs and surfaces",
"synonyms": [
"Protein surfaces",
"Protein structural features",
"Protein 3D motifs",
"Structural motifs",
"Protein structural motifs"
],
"description": "Structural features or common 3D motifs within protein structures, including the surface of a protein structure, such as biological interfaces with other molecules."
},
{
"id": 113,
"uri": "http://edamontology.org/topic_2814",
"label": "Protein structure analysis",
"synonyms": [
"Protein tertiary structure",
"Protein structure"
],
"description": "Protein secondary or tertiary structural data and/or associated annotation."
},
{
"id": 60,
"uri": "http://edamontology.org/topic_3325",
"label": "Rare diseases",
"synonyms": [
"Rare_disease"
],
"description": "The study of rare diseases."
},
{
"id": 73,
"uri": "http://edamontology.org/topic_0204",
"label": "Gene regulation",
"synonyms": [
"Regulatory genomics"
],
"description": "The regulation of gene expression."
},
{
"id": 13,
"uri": "http://edamontology.org/topic_3170",
"label": "RNA-Seq",
"synonyms": [
"RNA sequencing",
"RNA-Seq analysis",
"Whole transcriptome shotgun sequencing",
"WTSS",
"Small-Seq",
"Small RNA sequencing",
"Small RNA-Seq",
"miRNA-seq",
"MicroRNA sequencing",
"Transcriptome profiling"
],
"description": "A topic concerning high-throughput sequencing of cDNA to measure the RNA content (transcriptome) of a sample, for example, to investigate how different alleles of a gene are expressed, detect post-transcriptional mutations or identify gene fusions."
},
{
"id": 100,
"uri": "http://edamontology.org/topic_3068",
"label": "Literature and language",
"synonyms": [
"Scientific literature",
"Literature",
"Language",
"References",
"Documentation",
"Citations",
"Bibliography"
],
"description": "The scientific literature, language processing, reference information, and documentation."
},
{
"id": 35,
"uri": "http://edamontology.org/topic_0160",
"label": "Sequence sites, features and motifs",
"synonyms": [
"Sequence profiles",
"Sequence sites",
"Sequence motifs",
"HMMs",
"Functional sites",
"Sequence features"
],
"description": "The archival, detection, prediction and analysis of positional features such as functional and other key sites, in molecular sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 38,
"uri": "http://edamontology.org/topic_0080",
"label": "Sequence analysis",
"synonyms": [
"Sequences",
"Biological sequences",
"Sequence databases"
],
"description": "The archival, processing and analysis of molecular sequences (monomer composition of polymers) including molecular sequence data resources, sequence sites, alignments, motifs and profiles."
},
{
"id": 118,
"uri": "http://edamontology.org/topic_0099",
"label": "RNA",
"synonyms": [
"Small RNA"
],
"description": "RNA sequences and structures."
}
]
}