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            "id": 39,
            "uri": "http://edamontology.org/topic_0097",
            "label": "Nucleic acid structure analysis",
            "synonyms": [
                "DNA structure",
                "Nucleic acid structure",
                "Nucleic acid denaturation",
                "DNA melting",
                "RNA structure alignment",
                "RNA structure",
                "Nucleic acid thermodynamics",
                "RNA alignment"
            ],
            "description": "The archival, curation, processing and analysis of nucleic acid structural information, such as whole structures, structural features and alignments, and associated annotation."
        },
        {
            "id": 34,
            "uri": "http://edamontology.org/topic_3391",
            "label": "Omics",
            "synonyms": null,
            "description": "The collective characterisation and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms."
        },
        {
            "id": 55,
            "uri": "http://edamontology.org/topic_0089",
            "label": "Ontology and terminology",
            "synonyms": [
                "Upper ontology",
                "Terminology",
                "Ontology",
                "Ontologies",
                "Ontology relations",
                "Applied ontology"
            ],
            "description": "The conceptualisation, categorisation and nomenclature (naming) of entities or phenomena within biology or bioinformatics. This includes formal ontologies, controlled vocabularies, structured glossary, symbols and terminology or other related resource."
        },
        {
            "id": 69,
            "uri": "http://edamontology.org/topic_3943",
            "label": "Paleogenomics",
            "synonyms": [
                "Paleogenetics",
                "Ancestral genomes"
            ],
            "description": "The reconstruction and analysis of genomic information in extinct species."
        },
        {
            "id": 96,
            "uri": "http://edamontology.org/topic_0634",
            "label": "Pathology",
            "synonyms": [
                "Pathology",
                "Disease"
            ],
            "description": "Diseases, including diseases in general and the genes, gene variations and proteins involved in one or more specific diseases."
        },
        {
            "id": 2,
            "uri": "http://edamontology.org/topic_3519",
            "label": "PCR experiment",
            "synonyms": [
                "Polymerase chain reaction",
                "Real Time Quantitative PCR",
                "RT-qPCR",
                "Quantitative PCR"
            ],
            "description": "PCR experiments, e.g. quantitative real-time PCR."
        },
        {
            "id": 135,
            "uri": "http://edamontology.org/topic_3577",
            "label": "Personalised medicine",
            "synonyms": [
                "Precision medicine",
                "Molecular diagnostics"
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            "description": "An approach to medicine whereby decisions, practices and are tailored to the individual patient based on their predicted response or risk of disease."
        },
        {
            "id": 48,
            "uri": "http://edamontology.org/topic_3298",
            "label": "Phenomics",
            "synonyms": null,
            "description": "Phenomes, or the study of the change in phenotype (the physical and biochemical traits of organisms) in response to genetic and environmental factors."
        },
        {
            "id": 59,
            "uri": "http://edamontology.org/topic_3293",
            "label": "Phylogenetics",
            "synonyms": null,
            "description": "The study of evolutionary relationships amongst organisms from analysis of genetic information (typically gene or protein sequences)."
        },
        {
            "id": 68,
            "uri": "http://edamontology.org/topic_0194",
            "label": "Phylogenomics",
            "synonyms": null,
            "description": "The integrated study of evolutionary relationships and whole genome data, for example, in the analysis of species trees, horizontal gene transfer and evolutionary reconstruction."
        },
        {
            "id": 56,
            "uri": "http://edamontology.org/topic_0084",
            "label": "Phylogeny",
            "synonyms": [
                "Phylogenetic simulation",
                "Phylogenetic clocks",
                "Phylogeny reconstruction",
                "Phylogenetic stratigraphy",
                "Phylogenetic dating"
            ],
            "description": "The study of evolutionary relationships amongst organisms."
        },
        {
            "id": 136,
            "uri": "http://edamontology.org/topic_3300",
            "label": "Physiology",
            "synonyms": [
                "Electrophysiology"
            ],
            "description": "The functions of living organisms and their constituent parts."
        },
        {
            "id": 86,
            "uri": "http://edamontology.org/topic_0780",
            "label": "Plant biology",
            "synonyms": [
                "Plant",
                "Plant physiology",
                "Plant anatomy",
                "Plant ecology",
                "Plant genetics",
                "Botany",
                "Plant science",
                "Plants",
                "Plant cell biology"
            ],
            "description": "Plants, e.g. information on a specific plant genome including molecular sequences, genes and annotation."
        },
        {
            "id": 102,
            "uri": "http://edamontology.org/topic_3056",
            "label": "Population genetics",
            "synonyms": null,
            "description": "The distribution of allele frequencies in a population of organisms and its change subject to evolutionary processes including natural selection, genetic drift, mutation and gene flow."
        },
        {
            "id": 97,
            "uri": "http://edamontology.org/topic_0632",
            "label": "Probes and primers",
            "synonyms": [
                "Primers",
                "Primer quality",
                "Probes"
            ],
            "description": "Molecular probes (e.g. a peptide probe or DNA microarray probe) or PCR primers and hybridisation oligos in a nucleic acid sequence."
        },
        {
            "id": 19,
            "uri": "http://edamontology.org/topic_3534",
            "label": "Protein binding sites",
            "synonyms": [
                "Protein key folding sites",
                "Protein cleavage sites",
                "Enzyme active site",
                "Protein-nucleic acid binding sites",
                "Protein functional sites"
            ],
            "description": "Binding sites in proteins, including cleavage sites (for a proteolytic enzyme or agent), key residues involved in protein folding, catalytic residues (active site) of an enzyme, ligand-binding (non-catalytic) residues of a protein, such as sites that bind metal, prosthetic groups or lipids, RNA and DNA-binding proteins and binding sites etc."
        },
        {
            "id": 99,
            "uri": "http://edamontology.org/topic_0736",
            "label": "Protein folds and structural domains",
            "synonyms": [
                "Protein domains",
                "Protein membrane regions",
                "Protein folds",
                "Protein transmembrane regions",
                "Protein topological domains",
                "Protein structural domains",
                "Intramembrane regions",
                "Transmembrane regions"
            ],
            "description": "Protein tertiary structural domains and folds in a protein or polypeptide chain."
        },
        {
            "id": 89,
            "uri": "http://edamontology.org/topic_3957",
            "label": "Protein interaction experiment",
            "synonyms": [
                "Phage display",
                "Yeast one-hybrid",
                "Co-immunoprecipitation",
                "Yeast two-hybrid"
            ],
            "description": "An experiment for studying protein-protein interactions."
        },
        {
            "id": 24,
            "uri": "http://edamontology.org/topic_0128",
            "label": "Protein interactions",
            "synonyms": [
                "Protein interaction networks",
                "Protein-ligand interactions",
                "Protein-nucleic acid interactions",
                "Protein-DNA interactions",
                "Protein-DNA interaction",
                "Protein interaction map",
                "Protein-RNA interaction",
                "Protein-RNA interactions",
                "Protein interactome",
                "Protein-protein interactions"
            ],
            "description": "Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions."
        },
        {
            "id": 74,
            "uri": "http://edamontology.org/topic_0078",
            "label": "Proteins",
            "synonyms": [
                "Protein informatics",
                "Protein bioinformatics",
                "Protein databases"
            ],
            "description": "Archival, processing and analysis of protein data, typically molecular sequence and structural data."
        }
    ]
}