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"count": 136,
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{
"id": 80,
"uri": "http://edamontology.org/topic_0621",
"label": "Model organisms",
"synonyms": [
"Organisms"
],
"description": "A specific organism, or group of organisms, used to study a particular aspect of biology."
},
{
"id": 66,
"uri": "http://edamontology.org/topic_3511",
"label": "Nucleic acid sites, features and motifs",
"synonyms": [
"Nucleic acid functional sites",
"Primer binding sites",
"Nucleic acid sequence features",
"Sequence tagged sites"
],
"description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in nucleic acid sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 92,
"uri": "http://edamontology.org/topic_3320",
"label": "RNA splicing",
"synonyms": [
"Alternative splicing",
"Splice sites"
],
"description": "RNA splicing; post-transcription RNA modification involving the removal of introns and joining of exons."
},
{
"id": 35,
"uri": "http://edamontology.org/topic_0160",
"label": "Sequence sites, features and motifs",
"synonyms": [
"Sequence profiles",
"Sequence sites",
"Sequence motifs",
"HMMs",
"Functional sites",
"Sequence features"
],
"description": "The archival, detection, prediction and analysis of positional features such as functional and other key sites, in molecular sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 65,
"uri": "http://edamontology.org/topic_0749",
"label": "Transcription factors and regulatory sites",
"synonyms": [
"Attenuators",
"Transcription factors",
"GC signals",
"Terminators",
"-10 signals",
"TFBS",
"Isochores",
"-35 signals",
"Promoters",
"Enhancers",
"Transcriptional regulatory sites",
"TATA signals",
"CCAAT box",
"Transcription factor binding sites",
"CAAT signals",
"CAT box",
"CpG islands"
],
"description": "Proteins that bind to DNA and control transcription of DNA to mRNA (transcription factors) and also transcriptional regulatory sites, elements and regions (such as promoters, enhancers, silencers and boundary elements / insulators) in nucleotide sequences."
},
{
"id": 27,
"uri": "http://edamontology.org/topic_0203",
"label": "Gene expression",
"synonyms": [
"DNA chips",
"DNA microarrays",
"Gene translation",
"Transcription",
"Expression",
"Gene expression profiling",
"Codon usage",
"Gene transcription"
],
"description": "The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."
},
{
"id": 45,
"uri": "http://edamontology.org/topic_3174",
"label": "Metagenomics",
"synonyms": [
"Biome sequencing",
"Shotgun metagenomics"
],
"description": "The study of genetic material recovered from environmental samples, and associated environmental data."
},
{
"id": 25,
"uri": "http://edamontology.org/topic_3125",
"label": "DNA binding sites",
"synonyms": [
"Matrix-attachment region",
"Ribosome binding sites",
"Scaffold-attachment region",
"Matrix/scaffold attachment region",
"Nucleosome exclusion sequences",
"Restriction sites"
],
"description": "Nucleic acids binding to some other molecule."
},
{
"id": 30,
"uri": "http://edamontology.org/topic_2275",
"label": "Molecular modelling",
"synonyms": [
"Comparative modelling",
"Homology modeling",
"Docking",
"Homology modelling",
"Molecular docking"
],
"description": "The construction, analysis, evaluation, refinement etc. of models of a molecules properties or behaviour, including the modelling the structure of proteins in complex with small molecules or other macromolecules (docking)."
},
{
"id": 56,
"uri": "http://edamontology.org/topic_0084",
"label": "Phylogeny",
"synonyms": [
"Phylogenetic simulation",
"Phylogenetic clocks",
"Phylogeny reconstruction",
"Phylogenetic stratigraphy",
"Phylogenetic dating"
],
"description": "The study of evolutionary relationships amongst organisms."
},
{
"id": 51,
"uri": "http://edamontology.org/topic_3308",
"label": "Transcriptomics",
"synonyms": [
"Transcriptome",
"Comparative transcriptomics",
"Metatranscriptomics"
],
"description": "The analysis of transcriptomes, or a set of all the RNA molecules in a specific cell, tissue etc."
},
{
"id": 28,
"uri": "http://edamontology.org/topic_0081",
"label": "Structure analysis",
"synonyms": [
"Structural bioinformatics",
"Computational structural biology",
"Structure data resources",
"Molecular structure",
"Structures",
"Structure databases",
"Biomolecular structure"
],
"description": "The curation, processing, analysis and prediction of data about the structure of biological molecules, typically proteins and nucleic acids and other macromolecules."
},
{
"id": 9,
"uri": "http://edamontology.org/topic_0637",
"label": "Taxonomy",
"synonyms": null,
"description": "Organism classification, identification and naming."
},
{
"id": 22,
"uri": "http://edamontology.org/topic_0196",
"label": "Sequence assembly",
"synonyms": [
"Assembly"
],
"description": "The assembly of fragments of a DNA sequence to reconstruct the original sequence."
},
{
"id": 13,
"uri": "http://edamontology.org/topic_3170",
"label": "RNA-Seq",
"synonyms": [
"RNA sequencing",
"RNA-Seq analysis",
"Whole transcriptome shotgun sequencing",
"WTSS",
"Small-Seq",
"Small RNA sequencing",
"Small RNA-Seq",
"miRNA-seq",
"MicroRNA sequencing",
"Transcriptome profiling"
],
"description": "A topic concerning high-throughput sequencing of cDNA to measure the RNA content (transcriptome) of a sample, for example, to investigate how different alleles of a gene are expressed, detect post-transcriptional mutations or identify gene fusions."
},
{
"id": 105,
"uri": "http://edamontology.org/topic_3169",
"label": "ChIP-seq",
"synonyms": [
"ChIP-sequencing",
"Chip sequencing",
"Chip Seq",
"ChIP-exo",
"Chip-sequencing"
],
"description": "The analysis of protein-DNA interactions where chromatin immunoprecipitation (ChIP) is used in combination with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins."
},
{
"id": 81,
"uri": "http://edamontology.org/topic_0797",
"label": "Comparative genomics",
"synonyms": null,
"description": "The study (typically comparison) of the sequence, structure or function of multiple genomes."
},
{
"id": 18,
"uri": "http://edamontology.org/topic_0092",
"label": "Data visualisation",
"synonyms": [
"Data rendering"
],
"description": "Rendering (drawing on a computer screen) or visualisation of molecular sequences, structures or other biomolecular data."
},
{
"id": 72,
"uri": "http://edamontology.org/topic_0622",
"label": "Genomics",
"synonyms": [
"Exomes",
"Synthetic genomics",
"Genome annotation",
"Whole genomes",
"Personal genomics",
"Genomes",
"Viral genomics"
],
"description": "Whole genomes of one or more organisms, or genomes in general, such as meta-information on genomes, genome projects, gene names etc."
},
{
"id": 50,
"uri": "http://edamontology.org/topic_3510",
"label": "Protein sites, features and motifs",
"synonyms": [
"Protein sequence features",
"Signal peptide cleavage sites"
],
"description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in protein sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
}
]
}