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"count": 136,
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{
"id": 128,
"uri": "http://edamontology.org/topic_3175",
"label": "Structural variation",
"synonyms": [
"DNA structural variation",
"Genomic structural variation",
"Deletion",
"Duplication",
"Insertion",
"Inversion",
"Translocation"
],
"description": "Variation in chromosome structure including microscopic and submicroscopic types of variation such as deletions, duplications, copy-number variants, insertions, inversions and translocations."
},
{
"id": 45,
"uri": "http://edamontology.org/topic_3174",
"label": "Metagenomics",
"synonyms": [
"Biome sequencing",
"Shotgun metagenomics"
],
"description": "The study of genetic material recovered from environmental samples, and associated environmental data."
},
{
"id": 129,
"uri": "http://edamontology.org/topic_3173",
"label": "Epigenomics",
"synonyms": [],
"description": "The study of the epigenetic modifications of a whole cell, tissue, organism etc."
},
{
"id": 64,
"uri": "http://edamontology.org/topic_3172",
"label": "Metabolomics",
"synonyms": [
"Exometabolomics",
"Metabolites",
"Metabonomics",
"MS-based metabolomics",
"MS-based untargeted metabolomics",
"NMR-based metabolomics",
"Metabolome",
"LC-MS-based metabolomics",
"MS-based targeted metabolomics",
"Mass spectrometry-based metabolomics"
],
"description": "The systematic study of metabolites, the chemical processes they are involved, and the chemical fingerprints of specific cellular processes in a whole cell, tissue, organ or organism."
},
{
"id": 13,
"uri": "http://edamontology.org/topic_3170",
"label": "RNA-Seq",
"synonyms": [
"RNA sequencing",
"RNA-Seq analysis",
"Whole transcriptome shotgun sequencing",
"WTSS",
"Small-Seq",
"Small RNA sequencing",
"Small RNA-Seq",
"miRNA-seq",
"MicroRNA sequencing",
"Transcriptome profiling"
],
"description": "A topic concerning high-throughput sequencing of cDNA to measure the RNA content (transcriptome) of a sample, for example, to investigate how different alleles of a gene are expressed, detect post-transcriptional mutations or identify gene fusions."
},
{
"id": 105,
"uri": "http://edamontology.org/topic_3169",
"label": "ChIP-seq",
"synonyms": [
"ChIP-sequencing",
"Chip sequencing",
"Chip Seq",
"ChIP-exo",
"Chip-sequencing"
],
"description": "The analysis of protein-DNA interactions where chromatin immunoprecipitation (ChIP) is used in combination with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins."
},
{
"id": 23,
"uri": "http://edamontology.org/topic_3168",
"label": "Sequencing",
"synonyms": [
"Panels",
"Primer walking",
"DNA-Seq",
"High-throughput sequencing",
"Chromosome walking",
"Next generation sequencing",
"NGS data analysis",
"Next gen sequencing",
"High throughput sequencing",
"Targeted next-generation sequencing panels",
"NGS",
"Sanger sequencing",
"Clone verification",
"DNase-Seq"
],
"description": "The determination of complete (typically nucleotide) sequences, including those of genomes (full genome sequencing, de novo sequencing and resequencing), amplicons and transcriptomes."
},
{
"id": 25,
"uri": "http://edamontology.org/topic_3125",
"label": "DNA binding sites",
"synonyms": [
"Matrix-attachment region",
"Ribosome binding sites",
"Scaffold-attachment region",
"Matrix/scaffold attachment region",
"Nucleosome exclusion sequences",
"Restriction sites"
],
"description": "Nucleic acids binding to some other molecule."
},
{
"id": 8,
"uri": "http://edamontology.org/topic_3077",
"label": "Data acquisition",
"synonyms": [
"Data collection"
],
"description": "The acquisition of data, typically measurements of physical systems using any type of sampling system, or by another other means."
},
{
"id": 87,
"uri": "http://edamontology.org/topic_3071",
"label": "Biological databases",
"synonyms": [
"Data management",
"Databases and information systems",
"Information systems"
],
"description": "The development and use of architectures, policies, practices and procedures for management of data."
},
{
"id": 100,
"uri": "http://edamontology.org/topic_3068",
"label": "Literature and language",
"synonyms": [
"Scientific literature",
"Literature",
"Language",
"References",
"Documentation",
"Citations",
"Bibliography"
],
"description": "The scientific literature, language processing, reference information, and documentation."
},
{
"id": 54,
"uri": "http://edamontology.org/topic_3065",
"label": "Embryology",
"synonyms": null,
"description": "The development of organisms between the one-cell stage (typically the zygote) and the end of the embryonic stage."
},
{
"id": 57,
"uri": "http://edamontology.org/topic_3064",
"label": "Developmental biology",
"synonyms": [
"Development"
],
"description": "How organisms grow and develop."
},
{
"id": 61,
"uri": "http://edamontology.org/topic_3063",
"label": "Medical informatics",
"synonyms": [
"Biomedical informatics",
"Health and disease",
"Clinical informatics",
"Healthcare informatics",
"Health informatics"
],
"description": "The application of information technology to health, disease and biomedicine."
},
{
"id": 102,
"uri": "http://edamontology.org/topic_3056",
"label": "Population genetics",
"synonyms": null,
"description": "The distribution of allele frequencies in a population of organisms and its change subject to evolutionary processes including natural selection, genetic drift, mutation and gene flow."
},
{
"id": 63,
"uri": "http://edamontology.org/topic_3053",
"label": "Genetics",
"synonyms": [
"Genes",
"Heredity"
],
"description": "The study of genes, genetic variation and heredity in living organisms."
},
{
"id": 67,
"uri": "http://edamontology.org/topic_3050",
"label": "Biodiversity",
"synonyms": null,
"description": "The degree of variation of life forms within a given ecosystem, biome or an entire planet."
},
{
"id": 4,
"uri": "http://edamontology.org/topic_2885",
"label": "DNA polymorphism",
"synonyms": [
"Microsatellites",
"SNP",
"Variable number of tandem repeat polymorphism",
"snps",
"Single nucleotide polymorphism",
"VNTR",
"RFLP"
],
"description": "DNA polymorphism."
},
{
"id": 120,
"uri": "http://edamontology.org/topic_2840",
"label": "Toxicology",
"synonyms": [
"Toxicoinformatics",
"Computational toxicology"
],
"description": "Toxins and the adverse effects of these chemical substances on living organisms."
},
{
"id": 21,
"uri": "http://edamontology.org/topic_2828",
"label": "X-ray diffraction",
"synonyms": [
"X-ray crystallography",
"X-ray microscopy",
"Crystallography"
],
"description": "The study of matter and their structure by means of the diffraction of X-rays, typically the diffraction pattern caused by the regularly spaced atoms of a crystalline sample."
}
]
}