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            "id": 50,
            "uri": "http://edamontology.org/topic_3510",
            "label": "Protein sites, features and motifs",
            "synonyms": [
                "Protein sequence features",
                "Signal peptide cleavage sites"
            ],
            "description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in protein sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
        },
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            "id": 66,
            "uri": "http://edamontology.org/topic_3511",
            "label": "Nucleic acid sites, features and motifs",
            "synonyms": [
                "Nucleic acid functional sites",
                "Primer binding sites",
                "Nucleic acid sequence features",
                "Sequence tagged sites"
            ],
            "description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in nucleic acid sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
        },
        {
            "id": 22,
            "uri": "http://edamontology.org/topic_0196",
            "label": "Sequence assembly",
            "synonyms": [
                "Assembly"
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            "description": "The assembly of fragments of a DNA sequence to reconstruct the original sequence."
        },
        {
            "id": 41,
            "uri": "http://edamontology.org/topic_0157",
            "label": "Sequence composition, complexity and repeats",
            "synonyms": [
                "Protein sequence repeats",
                "Sequence complexity",
                "Low complexity sequences",
                "Nucleic acid repeats",
                "Repeat sequences",
                "Sequence composition",
                "Sequence repeats",
                "Protein repeats"
            ],
            "description": "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences."
        },
        {
            "id": 38,
            "uri": "http://edamontology.org/topic_0080",
            "label": "Sequence analysis",
            "synonyms": [
                "Sequences",
                "Biological sequences",
                "Sequence databases"
            ],
            "description": "The archival, processing and analysis of molecular sequences (monomer composition of polymers) including molecular sequence data resources, sequence sites, alignments, motifs and profiles."
        },
        {
            "id": 35,
            "uri": "http://edamontology.org/topic_0160",
            "label": "Sequence sites, features and motifs",
            "synonyms": [
                "Sequence profiles",
                "Sequence sites",
                "Sequence motifs",
                "HMMs",
                "Functional sites",
                "Sequence features"
            ],
            "description": "The archival, detection, prediction and analysis of positional features such as functional and other key sites, in molecular sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
        },
        {
            "id": 39,
            "uri": "http://edamontology.org/topic_0097",
            "label": "Nucleic acid structure analysis",
            "synonyms": [
                "DNA structure",
                "Nucleic acid structure",
                "Nucleic acid denaturation",
                "DNA melting",
                "RNA structure alignment",
                "RNA structure",
                "Nucleic acid thermodynamics",
                "RNA alignment"
            ],
            "description": "The archival, curation, processing and analysis of nucleic acid structural information, such as whole structures, structural features and alignments, and associated annotation."
        },
        {
            "id": 88,
            "uri": "http://edamontology.org/topic_0091",
            "label": "Bioinformatics",
            "synonyms": null,
            "description": "The archival, curation, processing and analysis of complex biological data."
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            "id": 14,
            "uri": "http://edamontology.org/topic_2269",
            "label": "Statistics and probability",
            "synonyms": [
                "Biostatistics",
                "Multivariate statistics",
                "Bayesian methods",
                "Gaussian processes",
                "Probability",
                "Markov processes",
                "Probabilistic graphical model",
                "Inferential statistics",
                "Descriptive statistics",
                "Statistics"
            ],
            "description": "The application of statistical methods to biological problems."
        },
        {
            "id": 110,
            "uri": "http://edamontology.org/topic_0804",
            "label": "Immunology",
            "synonyms": null,
            "description": "The application of information technology to immunology such as immunological processes, immunological genes, proteins and peptide ligands, antigens and so on."
        },
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            "id": 61,
            "uri": "http://edamontology.org/topic_3063",
            "label": "Medical informatics",
            "synonyms": [
                "Biomedical informatics",
                "Health and disease",
                "Clinical informatics",
                "Healthcare informatics",
                "Health informatics"
            ],
            "description": "The application of information technology to health, disease and biomedicine."
        },
        {
            "id": 51,
            "uri": "http://edamontology.org/topic_3308",
            "label": "Transcriptomics",
            "synonyms": [
                "Transcriptome",
                "Comparative transcriptomics",
                "Metatranscriptomics"
            ],
            "description": "The analysis of transcriptomes, or a set of all the RNA molecules in a specific cell, tissue etc."
        },
        {
            "id": 105,
            "uri": "http://edamontology.org/topic_3169",
            "label": "ChIP-seq",
            "synonyms": [
                "ChIP-sequencing",
                "Chip sequencing",
                "Chip Seq",
                "ChIP-exo",
                "Chip-sequencing"
            ],
            "description": "The analysis of protein-DNA interactions where chromatin immunoprecipitation (ChIP) is used in combination with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins."
        },
        {
            "id": 27,
            "uri": "http://edamontology.org/topic_0203",
            "label": "Gene expression",
            "synonyms": [
                "DNA chips",
                "DNA microarrays",
                "Gene translation",
                "Transcription",
                "Expression",
                "Gene expression profiling",
                "Codon usage",
                "Gene transcription"
            ],
            "description": "The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."
        },
        {
            "id": 8,
            "uri": "http://edamontology.org/topic_3077",
            "label": "Data acquisition",
            "synonyms": [
                "Data collection"
            ],
            "description": "The acquisition of data, typically measurements of physical systems using any type of sampling system, or by another other means."
        },
        {
            "id": 90,
            "uri": "http://edamontology.org/topic_0781",
            "label": "Virology",
            "synonyms": null,
            "description": "Study of viruses, e.g. sequence and structural data, interactions of viral proteins, or a viral genome including molecular sequences, genes and annotation."
        },
        {
            "id": 115,
            "uri": "http://edamontology.org/topic_0166",
            "label": "Protein structural motifs and surfaces",
            "synonyms": [
                "Protein surfaces",
                "Protein structural features",
                "Protein 3D motifs",
                "Structural motifs",
                "Protein structural motifs"
            ],
            "description": "Structural features or common 3D motifs within protein structures, including the surface of a protein structure, such as biological interfaces with other molecules."
        },
        {
            "id": 93,
            "uri": "http://edamontology.org/topic_0199",
            "label": "Genetic variation",
            "synonyms": [
                "DNA variation",
                "Somatic mutations",
                "Genomic variation",
                "Mutation",
                "Polymorphism"
            ],
            "description": "Stable, naturally occuring mutations in a nucleotide sequence including alleles, naturally occurring mutations such as single base nucleotide substitutions, deletions and insertions, RFLPs and other polymorphisms."
        },
        {
            "id": 20,
            "uri": "http://edamontology.org/topic_0154",
            "label": "Small molecules",
            "synonyms": [
                "Peptides and amino acids",
                "Toxins and targets",
                "Drugs and target structures",
                "Drug targets",
                "Peptides",
                "Drug structures",
                "Metabolite structures",
                "Amino acids",
                "Toxins",
                "Targets",
                "Chemical structures",
                "Target structures"
            ],
            "description": "Small molecules of biological significance, typically archival, curation, processing and analysis of structural information."
        },
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            "id": 116,
            "uri": "http://edamontology.org/topic_3542",
            "label": "Protein secondary structure",
            "synonyms": [
                "Protein super-secondary structure",
                "Protein features (secondary structure)"
            ],
            "description": "Secondary structure (predicted or real) of a protein, including super-secondary structure."
        }
    ]
}