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"count": 137,
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{
"id": 42,
"uri": "http://edamontology.org/topic_3366",
"label": "Data integration and warehousing",
"synonyms": [
"Data integration",
"Data warehousing"
],
"description": "The combination and integration of data from different sources, for example into a central repository or warehouse, to provide users with a unified view of these data."
},
{
"id": 44,
"uri": "http://edamontology.org/topic_3941",
"label": "Metatranscriptomics",
"synonyms": null,
"description": "The study of microbe gene expression within natural environments (i.e. the metatranscriptome)."
},
{
"id": 19,
"uri": "http://edamontology.org/topic_3534",
"label": "Protein binding sites",
"synonyms": [
"Protein key folding sites",
"Protein cleavage sites",
"Enzyme active site",
"Protein-nucleic acid binding sites",
"Protein functional sites"
],
"description": "Binding sites in proteins, including cleavage sites (for a proteolytic enzyme or agent), key residues involved in protein folding, catalytic residues (active site) of an enzyme, ligand-binding (non-catalytic) residues of a protein, such as sites that bind metal, prosthetic groups or lipids, RNA and DNA-binding proteins and binding sites etc."
},
{
"id": 103,
"uri": "http://edamontology.org/topic_0659",
"label": "Functional, regulatory and non-coding RNA",
"synonyms": [
"lncRNA",
"Small ncRNA",
"Small interfering RNA",
"Small nuclear RNA",
"siRNA",
"ncRNA",
"snRNA",
"snoRNA",
"Long non-coding RNA",
"Functional RNA",
"piwi-interacting RNA",
"piRNA",
"Long ncRNA",
"microRNA",
"miRNA",
"Small nucleolar RNA",
"Small and long non-coding RNAs",
"Non-coding RNA",
"Small non-coding RNA",
"Regulatory RNA"
],
"description": "Non-coding or functional RNA sequences, including regulatory RNA sequences, ribosomal RNA (rRNA) and transfer RNA (tRNA)."
},
{
"id": 41,
"uri": "http://edamontology.org/topic_0157",
"label": "Sequence composition, complexity and repeats",
"synonyms": [
"Protein sequence repeats",
"Sequence complexity",
"Low complexity sequences",
"Nucleic acid repeats",
"Repeat sequences",
"Sequence composition",
"Sequence repeats",
"Protein repeats"
],
"description": "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences."
},
{
"id": 5,
"uri": "http://edamontology.org/topic_3572",
"label": "Data quality management",
"synonyms": [
"Data integrity",
"Data cleaning",
"Data quality",
"Data clean-up"
],
"description": "The quality, integrity, and cleaning up of data."
},
{
"id": 76,
"uri": "http://edamontology.org/topic_3332",
"label": "Computational chemistry",
"synonyms": null,
"description": "Topic concerning the development and application of theory, analytical methods, mathematical models and computational simulation of chemical systems."
},
{
"id": 83,
"uri": "http://edamontology.org/topic_3301",
"label": "Microbiology",
"synonyms": [
"Microbial physiology",
"Microbial genetics",
"Microbiological surveillance",
"Molecular microbiology",
"Medical microbiology",
"Antimicrobial stewardship",
"Microbial surveillance",
"Molecular infection biology"
],
"description": "The biology of microorganisms."
},
{
"id": 98,
"uri": "http://edamontology.org/topic_3518",
"label": "Microarray experiment",
"synonyms": [
"miRNA array",
"Proprietary platform micoarray",
"MicroRNA array",
"Gene expression microarray",
"Multichannel microarray",
"RNA microarrays",
"Microarrays",
"mRNA microarray",
"Reverse phase protein array",
"One channel microarray",
"aCGH microarray",
"Tissue microarray",
"SNP array",
"Methylation array",
"Tiling arrays",
"RNA chips",
"Genotyping array",
"Two channel microarray"
],
"description": "Microarray experiments including conditions, protocol, sample:data relationships etc."
},
{
"id": 39,
"uri": "http://edamontology.org/topic_0097",
"label": "Nucleic acid structure analysis",
"synonyms": [
"DNA structure",
"Nucleic acid structure",
"Nucleic acid denaturation",
"DNA melting",
"RNA structure alignment",
"RNA structure",
"Nucleic acid thermodynamics",
"RNA alignment"
],
"description": "The archival, curation, processing and analysis of nucleic acid structural information, such as whole structures, structural features and alignments, and associated annotation."
},
{
"id": 46,
"uri": "http://edamontology.org/topic_3387",
"label": "Marine biology",
"synonyms": null,
"description": "The study of organisms in the ocean or brackish waters."
},
{
"id": 111,
"uri": "http://edamontology.org/topic_0121",
"label": "Proteomics",
"synonyms": [
"Peptide identification",
"Quantitative proteomics",
"MS-based targeted proteomics",
"Targeted proteomics",
"Metaproteomics",
"MS-based untargeted proteomics",
"Discovery proteomics",
"Top-down proteomics",
"Protein and peptide identification",
"Bottom-up proteomics"
],
"description": "Protein and peptide identification, especially in the study of whole proteomes of organisms."
},
{
"id": 81,
"uri": "http://edamontology.org/topic_0797",
"label": "Comparative genomics",
"synonyms": null,
"description": "The study (typically comparison) of the sequence, structure or function of multiple genomes."
},
{
"id": 56,
"uri": "http://edamontology.org/topic_0084",
"label": "Phylogeny",
"synonyms": [
"Phylogenetic simulation",
"Phylogenetic clocks",
"Phylogeny reconstruction",
"Phylogenetic stratigraphy",
"Phylogenetic dating"
],
"description": "The study of evolutionary relationships amongst organisms."
},
{
"id": 30,
"uri": "http://edamontology.org/topic_2275",
"label": "Molecular modelling",
"synonyms": [
"Comparative modelling",
"Homology modeling",
"Docking",
"Homology modelling",
"Molecular docking"
],
"description": "The construction, analysis, evaluation, refinement etc. of models of a molecules properties or behaviour, including the modelling the structure of proteins in complex with small molecules or other macromolecules (docking)."
},
{
"id": 50,
"uri": "http://edamontology.org/topic_3510",
"label": "Protein sites, features and motifs",
"synonyms": [
"Protein sequence features",
"Signal peptide cleavage sites"
],
"description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in protein sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 27,
"uri": "http://edamontology.org/topic_0203",
"label": "Gene expression",
"synonyms": [
"DNA chips",
"DNA microarrays",
"Gene translation",
"Transcription",
"Expression",
"Gene expression profiling",
"Codon usage",
"Gene transcription"
],
"description": "The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."
},
{
"id": 13,
"uri": "http://edamontology.org/topic_3170",
"label": "RNA-Seq",
"synonyms": [
"RNA sequencing",
"RNA-Seq analysis",
"Whole transcriptome shotgun sequencing",
"WTSS",
"Small-Seq",
"Small RNA sequencing",
"Small RNA-Seq",
"miRNA-seq",
"MicroRNA sequencing",
"Transcriptome profiling"
],
"description": "A topic concerning high-throughput sequencing of cDNA to measure the RNA content (transcriptome) of a sample, for example, to investigate how different alleles of a gene are expressed, detect post-transcriptional mutations or identify gene fusions."
},
{
"id": 66,
"uri": "http://edamontology.org/topic_3511",
"label": "Nucleic acid sites, features and motifs",
"synonyms": [
"Nucleic acid functional sites",
"Primer binding sites",
"Nucleic acid sequence features",
"Sequence tagged sites"
],
"description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in nucleic acid sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 80,
"uri": "http://edamontology.org/topic_0621",
"label": "Model organisms",
"synonyms": [
"Organisms"
],
"description": "A specific organism, or group of organisms, used to study a particular aspect of biology."
}
]
}