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{
"id": 65,
"uri": "http://edamontology.org/topic_0749",
"label": "Transcription factors and regulatory sites",
"synonyms": [
"Attenuators",
"Transcription factors",
"GC signals",
"Terminators",
"-10 signals",
"TFBS",
"Isochores",
"-35 signals",
"Promoters",
"Enhancers",
"Transcriptional regulatory sites",
"TATA signals",
"CCAAT box",
"Transcription factor binding sites",
"CAAT signals",
"CAT box",
"CpG islands"
],
"description": "Proteins that bind to DNA and control transcription of DNA to mRNA (transcription factors) and also transcriptional regulatory sites, elements and regions (such as promoters, enhancers, silencers and boundary elements / insulators) in nucleotide sequences."
},
{
"id": 99,
"uri": "http://edamontology.org/topic_0736",
"label": "Protein folds and structural domains",
"synonyms": [
"Protein domains",
"Protein membrane regions",
"Protein folds",
"Protein transmembrane regions",
"Protein topological domains",
"Protein structural domains",
"Intramembrane regions",
"Transmembrane regions"
],
"description": "Protein tertiary structural domains and folds in a protein or polypeptide chain."
},
{
"id": 106,
"uri": "http://edamontology.org/topic_3520",
"label": "Proteomics experiment",
"synonyms": [
"2D PAGE experiment",
"Spectrum demultiplexing",
"Mass spectrometry experiments",
"MS",
"Northern blot experiment",
"MS experiments",
"DIA",
"Mass spectrometry",
"Data-independent acquisition"
],
"description": "Proteomics experiments."
},
{
"id": 18,
"uri": "http://edamontology.org/topic_0092",
"label": "Data visualisation",
"synonyms": [
"Data rendering"
],
"description": "Rendering (drawing on a computer screen) or visualisation of molecular sequences, structures or other biomolecular data."
},
{
"id": 108,
"uri": "http://edamontology.org/topic_3523",
"label": "RNAi experiment",
"synonyms": null,
"description": "RNAi experiments."
},
{
"id": 118,
"uri": "http://edamontology.org/topic_0099",
"label": "RNA",
"synonyms": [
"Small RNA"
],
"description": "RNA sequences and structures."
},
{
"id": 92,
"uri": "http://edamontology.org/topic_3320",
"label": "RNA splicing",
"synonyms": [
"Alternative splicing",
"Splice sites"
],
"description": "RNA splicing; post-transcription RNA modification involving the removal of introns and joining of exons."
},
{
"id": 116,
"uri": "http://edamontology.org/topic_3542",
"label": "Protein secondary structure",
"synonyms": [
"Protein super-secondary structure",
"Protein features (secondary structure)"
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"description": "Secondary structure (predicted or real) of a protein, including super-secondary structure."
},
{
"id": 20,
"uri": "http://edamontology.org/topic_0154",
"label": "Small molecules",
"synonyms": [
"Peptides and amino acids",
"Toxins and targets",
"Drugs and target structures",
"Drug targets",
"Peptides",
"Drug structures",
"Metabolite structures",
"Amino acids",
"Toxins",
"Targets",
"Chemical structures",
"Target structures"
],
"description": "Small molecules of biological significance, typically archival, curation, processing and analysis of structural information."
},
{
"id": 93,
"uri": "http://edamontology.org/topic_0199",
"label": "Genetic variation",
"synonyms": [
"DNA variation",
"Somatic mutations",
"Genomic variation",
"Mutation",
"Polymorphism"
],
"description": "Stable, naturally occuring mutations in a nucleotide sequence including alleles, naturally occurring mutations such as single base nucleotide substitutions, deletions and insertions, RFLPs and other polymorphisms."
},
{
"id": 115,
"uri": "http://edamontology.org/topic_0166",
"label": "Protein structural motifs and surfaces",
"synonyms": [
"Protein surfaces",
"Protein structural features",
"Protein 3D motifs",
"Structural motifs",
"Protein structural motifs"
],
"description": "Structural features or common 3D motifs within protein structures, including the surface of a protein structure, such as biological interfaces with other molecules."
},
{
"id": 90,
"uri": "http://edamontology.org/topic_0781",
"label": "Virology",
"synonyms": null,
"description": "Study of viruses, e.g. sequence and structural data, interactions of viral proteins, or a viral genome including molecular sequences, genes and annotation."
},
{
"id": 8,
"uri": "http://edamontology.org/topic_3077",
"label": "Data acquisition",
"synonyms": [
"Data collection"
],
"description": "The acquisition of data, typically measurements of physical systems using any type of sampling system, or by another other means."
},
{
"id": 27,
"uri": "http://edamontology.org/topic_0203",
"label": "Gene expression",
"synonyms": [
"DNA chips",
"DNA microarrays",
"Gene translation",
"Transcription",
"Expression",
"Gene expression profiling",
"Codon usage",
"Gene transcription"
],
"description": "The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."
},
{
"id": 105,
"uri": "http://edamontology.org/topic_3169",
"label": "ChIP-seq",
"synonyms": [
"ChIP-sequencing",
"Chip sequencing",
"Chip Seq",
"ChIP-exo",
"Chip-sequencing"
],
"description": "The analysis of protein-DNA interactions where chromatin immunoprecipitation (ChIP) is used in combination with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins."
},
{
"id": 51,
"uri": "http://edamontology.org/topic_3308",
"label": "Transcriptomics",
"synonyms": [
"Transcriptome",
"Comparative transcriptomics",
"Metatranscriptomics"
],
"description": "The analysis of transcriptomes, or a set of all the RNA molecules in a specific cell, tissue etc."
},
{
"id": 61,
"uri": "http://edamontology.org/topic_3063",
"label": "Medical informatics",
"synonyms": [
"Biomedical informatics",
"Health and disease",
"Clinical informatics",
"Healthcare informatics",
"Health informatics"
],
"description": "The application of information technology to health, disease and biomedicine."
},
{
"id": 110,
"uri": "http://edamontology.org/topic_0804",
"label": "Immunology",
"synonyms": null,
"description": "The application of information technology to immunology such as immunological processes, immunological genes, proteins and peptide ligands, antigens and so on."
},
{
"id": 14,
"uri": "http://edamontology.org/topic_2269",
"label": "Statistics and probability",
"synonyms": [
"Biostatistics",
"Multivariate statistics",
"Bayesian methods",
"Gaussian processes",
"Probability",
"Markov processes",
"Probabilistic graphical model",
"Inferential statistics",
"Descriptive statistics",
"Statistics"
],
"description": "The application of statistical methods to biological problems."
},
{
"id": 88,
"uri": "http://edamontology.org/topic_0091",
"label": "Bioinformatics",
"synonyms": null,
"description": "The archival, curation, processing and analysis of complex biological data."
}
]
}