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{
"id": 116,
"uri": "http://edamontology.org/topic_3542",
"label": "Protein secondary structure",
"synonyms": [
"Protein super-secondary structure",
"Protein features (secondary structure)"
],
"description": "Secondary structure (predicted or real) of a protein, including super-secondary structure."
},
{
"id": 58,
"uri": "http://edamontology.org/topic_2229",
"label": "Cell biology",
"synonyms": [
"Protein subcellular localization",
"Cellular processes",
"Cells"
],
"description": "Cells, such as key genes and proteins involved in the cell cycle."
},
{
"id": 41,
"uri": "http://edamontology.org/topic_0157",
"label": "Sequence composition, complexity and repeats",
"synonyms": [
"Protein sequence repeats",
"Sequence complexity",
"Low complexity sequences",
"Nucleic acid repeats",
"Repeat sequences",
"Sequence composition",
"Sequence repeats",
"Protein repeats"
],
"description": "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences."
},
{
"id": 50,
"uri": "http://edamontology.org/topic_3510",
"label": "Protein sites, features and motifs",
"synonyms": [
"Protein sequence features",
"Signal peptide cleavage sites"
],
"description": "The biology, archival, detection, prediction and analysis of positional features such as functional and other key sites, in protein sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 19,
"uri": "http://edamontology.org/topic_3534",
"label": "Protein binding sites",
"synonyms": [
"Protein key folding sites",
"Protein cleavage sites",
"Enzyme active site",
"Protein-nucleic acid binding sites",
"Protein functional sites"
],
"description": "Binding sites in proteins, including cleavage sites (for a proteolytic enzyme or agent), key residues involved in protein folding, catalytic residues (active site) of an enzyme, ligand-binding (non-catalytic) residues of a protein, such as sites that bind metal, prosthetic groups or lipids, RNA and DNA-binding proteins and binding sites etc."
},
{
"id": 24,
"uri": "http://edamontology.org/topic_0128",
"label": "Protein interactions",
"synonyms": [
"Protein interaction networks",
"Protein-ligand interactions",
"Protein-nucleic acid interactions",
"Protein-DNA interactions",
"Protein-DNA interaction",
"Protein interaction map",
"Protein-RNA interaction",
"Protein-RNA interactions",
"Protein interactome",
"Protein-protein interactions"
],
"description": "Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions."
},
{
"id": 74,
"uri": "http://edamontology.org/topic_0078",
"label": "Proteins",
"synonyms": [
"Protein informatics",
"Protein bioinformatics",
"Protein databases"
],
"description": "Archival, processing and analysis of protein data, typically molecular sequence and structural data."
},
{
"id": 114,
"uri": "http://edamontology.org/topic_1775",
"label": "Function analysis",
"synonyms": [
"Protein function analysis",
"Protein function prediction",
"Functional analysis"
],
"description": "The study of gene and protein function including the prediction of functional properties of a protein."
},
{
"id": 31,
"uri": "http://edamontology.org/topic_0176",
"label": "Molecular dynamics",
"synonyms": [
"Protein dynamics"
],
"description": "The study and simulation of molecular (typically protein) conformation using a computational model of physical forces and computer simulation."
},
{
"id": 99,
"uri": "http://edamontology.org/topic_0736",
"label": "Protein folds and structural domains",
"synonyms": [
"Protein domains",
"Protein membrane regions",
"Protein folds",
"Protein transmembrane regions",
"Protein topological domains",
"Protein structural domains",
"Intramembrane regions",
"Transmembrane regions"
],
"description": "Protein tertiary structural domains and folds in a protein or polypeptide chain."
},
{
"id": 97,
"uri": "http://edamontology.org/topic_0632",
"label": "Probes and primers",
"synonyms": [
"Primers",
"Primer quality",
"Probes"
],
"description": "Molecular probes (e.g. a peptide probe or DNA microarray probe) or PCR primers and hybridisation oligos in a nucleic acid sequence."
},
{
"id": 2,
"uri": "http://edamontology.org/topic_3519",
"label": "PCR experiment",
"synonyms": [
"Polymerase chain reaction",
"Real Time Quantitative PCR",
"RT-qPCR",
"Quantitative PCR"
],
"description": "PCR experiments, e.g. quantitative real-time PCR."
},
{
"id": 86,
"uri": "http://edamontology.org/topic_0780",
"label": "Plant biology",
"synonyms": [
"Plant",
"Plant physiology",
"Plant anatomy",
"Plant ecology",
"Plant genetics",
"Botany",
"Plant science",
"Plants",
"Plant cell biology"
],
"description": "Plants, e.g. information on a specific plant genome including molecular sequences, genes and annotation."
},
{
"id": 56,
"uri": "http://edamontology.org/topic_0084",
"label": "Phylogeny",
"synonyms": [
"Phylogenetic simulation",
"Phylogenetic clocks",
"Phylogeny reconstruction",
"Phylogenetic stratigraphy",
"Phylogenetic dating"
],
"description": "The study of evolutionary relationships amongst organisms."
},
{
"id": 62,
"uri": "http://edamontology.org/topic_0625",
"label": "Genotype and phenotype",
"synonyms": [
"Phenotype",
"Genotyping",
"Genotype-phenotype analysis",
"Phenotyping",
"Genotype",
"Genotype and phenotype resources",
"Genotype-phenotype"
],
"description": "The study of genetic constitution of a living entity, such as an individual, and organism, a cell and so on, typically with respect to a particular observable phenotypic traits, or resources concerning such traits, which might be an aspect of biochemistry, physiology, morphology, anatomy, development and so on."
},
{
"id": 89,
"uri": "http://edamontology.org/topic_3957",
"label": "Protein interaction experiment",
"synonyms": [
"Phage display",
"Yeast one-hybrid",
"Co-immunoprecipitation",
"Yeast two-hybrid"
],
"description": "An experiment for studying protein-protein interactions."
},
{
"id": 20,
"uri": "http://edamontology.org/topic_0154",
"label": "Small molecules",
"synonyms": [
"Peptides and amino acids",
"Toxins and targets",
"Drugs and target structures",
"Drug targets",
"Peptides",
"Drug structures",
"Metabolite structures",
"Amino acids",
"Toxins",
"Targets",
"Chemical structures",
"Target structures"
],
"description": "Small molecules of biological significance, typically archival, curation, processing and analysis of structural information."
},
{
"id": 111,
"uri": "http://edamontology.org/topic_0121",
"label": "Proteomics",
"synonyms": [
"Peptide identification",
"Quantitative proteomics",
"MS-based targeted proteomics",
"Targeted proteomics",
"Metaproteomics",
"MS-based untargeted proteomics",
"Discovery proteomics",
"Top-down proteomics",
"Protein and peptide identification",
"Bottom-up proteomics"
],
"description": "Protein and peptide identification, especially in the study of whole proteomes of organisms."
},
{
"id": 96,
"uri": "http://edamontology.org/topic_0634",
"label": "Pathology",
"synonyms": [
"Pathology",
"Disease"
],
"description": "Diseases, including diseases in general and the genes, gene variations and proteins involved in one or more specific diseases."
},
{
"id": 23,
"uri": "http://edamontology.org/topic_3168",
"label": "Sequencing",
"synonyms": [
"Panels",
"Primer walking",
"DNA-Seq",
"High-throughput sequencing",
"Chromosome walking",
"Next generation sequencing",
"NGS data analysis",
"Next gen sequencing",
"High throughput sequencing",
"Targeted next-generation sequencing panels",
"NGS",
"Sanger sequencing",
"Clone verification",
"DNase-Seq"
],
"description": "The determination of complete (typically nucleotide) sequences, including those of genomes (full genome sequencing, de novo sequencing and resequencing), amplicons and transcriptomes."
}
]
}