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{
"id": 21,
"uri": "http://edamontology.org/topic_2828",
"label": "X-ray diffraction",
"synonyms": [
"X-ray crystallography",
"X-ray microscopy",
"Crystallography"
],
"description": "The study of matter and their structure by means of the diffraction of X-rays, typically the diffraction pattern caused by the regularly spaced atoms of a crystalline sample."
},
{
"id": 22,
"uri": "http://edamontology.org/topic_0196",
"label": "Sequence assembly",
"synonyms": [
"Assembly"
],
"description": "The assembly of fragments of a DNA sequence to reconstruct the original sequence."
},
{
"id": 23,
"uri": "http://edamontology.org/topic_3168",
"label": "Sequencing",
"synonyms": [
"Panels",
"Primer walking",
"DNA-Seq",
"High-throughput sequencing",
"Chromosome walking",
"Next generation sequencing",
"NGS data analysis",
"Next gen sequencing",
"High throughput sequencing",
"Targeted next-generation sequencing panels",
"NGS",
"Sanger sequencing",
"Clone verification",
"DNase-Seq"
],
"description": "The determination of complete (typically nucleotide) sequences, including those of genomes (full genome sequencing, de novo sequencing and resequencing), amplicons and transcriptomes."
},
{
"id": 24,
"uri": "http://edamontology.org/topic_0128",
"label": "Protein interactions",
"synonyms": [
"Protein interaction networks",
"Protein-ligand interactions",
"Protein-nucleic acid interactions",
"Protein-DNA interactions",
"Protein-DNA interaction",
"Protein interaction map",
"Protein-RNA interaction",
"Protein-RNA interactions",
"Protein interactome",
"Protein-protein interactions"
],
"description": "Protein-protein, protein-DNA/RNA and protein-ligand interactions, including analysis of known interactions and prediction of putative interactions."
},
{
"id": 25,
"uri": "http://edamontology.org/topic_3125",
"label": "DNA binding sites",
"synonyms": [
"Matrix-attachment region",
"Ribosome binding sites",
"Scaffold-attachment region",
"Matrix/scaffold attachment region",
"Nucleosome exclusion sequences",
"Restriction sites"
],
"description": "Nucleic acids binding to some other molecule."
},
{
"id": 26,
"uri": "http://edamontology.org/topic_3512",
"label": "Gene transcripts",
"synonyms": [
"Exons",
"Introns",
"PolyA site",
"EST",
"Gene transcript features",
"Transit peptide coding sequence",
"mRNA",
"Fusion transcripts",
"Coding RNA",
"PolyA signal",
"mRNA features",
"cDNA",
"Signal peptide coding sequence"
],
"description": "Transcription of DNA into RNA and features of a messenger RNA (mRNA) molecules including precursor RNA, primary (unprocessed) transcript and fully processed molecules."
},
{
"id": 27,
"uri": "http://edamontology.org/topic_0203",
"label": "Gene expression",
"synonyms": [
"DNA chips",
"DNA microarrays",
"Gene translation",
"Transcription",
"Expression",
"Gene expression profiling",
"Codon usage",
"Gene transcription"
],
"description": "The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data."
},
{
"id": 28,
"uri": "http://edamontology.org/topic_0081",
"label": "Structure analysis",
"synonyms": [
"Structural bioinformatics",
"Computational structural biology",
"Structure data resources",
"Molecular structure",
"Structures",
"Structure databases",
"Biomolecular structure"
],
"description": "The curation, processing, analysis and prediction of data about the structure of biological molecules, typically proteins and nucleic acids and other macromolecules."
},
{
"id": 29,
"uri": "http://edamontology.org/topic_3306",
"label": "Biophysics",
"synonyms": [
"Medical physics"
],
"description": "The use of physics to study biological system."
},
{
"id": 30,
"uri": "http://edamontology.org/topic_2275",
"label": "Molecular modelling",
"synonyms": [
"Comparative modelling",
"Homology modeling",
"Docking",
"Homology modelling",
"Molecular docking"
],
"description": "The construction, analysis, evaluation, refinement etc. of models of a molecules properties or behaviour, including the modelling the structure of proteins in complex with small molecules or other macromolecules (docking)."
},
{
"id": 31,
"uri": "http://edamontology.org/topic_0176",
"label": "Molecular dynamics",
"synonyms": [
"Protein dynamics"
],
"description": "The study and simulation of molecular (typically protein) conformation using a computational model of physical forces and computer simulation."
},
{
"id": 32,
"uri": "http://edamontology.org/topic_0593",
"label": "NMR",
"synonyms": [
"Nuclear Overhauser Effect Spectroscopy",
"Rotational Frame Nuclear Overhauser Effect Spectroscopy",
"ROESY",
"Nuclear magnetic resonance spectroscopy",
"NOESY",
"NMR spectroscopy",
"Heteronuclear Overhauser Effect Spectroscopy",
"HOESY"
],
"description": "An analytical technique that exploits the magenetic properties of certain atomic nuclei to provide information on the structure, dynamics, reaction state and chemical environment of molecules."
},
{
"id": 33,
"uri": "http://edamontology.org/topic_1317",
"label": "Structural biology",
"synonyms": [
"Structural determination",
"Structural assignment",
"Structure determination"
],
"description": "The molecular structure of biological molecules, particularly macromolecules such as proteins and nucleic acids."
},
{
"id": 34,
"uri": "http://edamontology.org/topic_3391",
"label": "Omics",
"synonyms": null,
"description": "The collective characterisation and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms."
},
{
"id": 35,
"uri": "http://edamontology.org/topic_0160",
"label": "Sequence sites, features and motifs",
"synonyms": [
"Sequence profiles",
"Sequence sites",
"Sequence motifs",
"HMMs",
"Functional sites",
"Sequence features"
],
"description": "The archival, detection, prediction and analysis of positional features such as functional and other key sites, in molecular sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
{
"id": 36,
"uri": "http://edamontology.org/topic_3930",
"label": "Immunogenetics",
"synonyms": [
"Immune system genetics",
"Immunology and genetics",
"Immunogenes",
"Immungenetics"
],
"description": "A biomedical field that bridges immunology and genetics, to study the genetic basis of the immune system."
},
{
"id": 37,
"uri": "http://edamontology.org/topic_3948",
"label": "Immunoinformatics",
"synonyms": [
"Computational immunology"
],
"description": "Immunoinformatics is the field of computational biology that deals with the study of immunoloogical questions. Immunoinformatics is at the interface between immunology and computer science. It takes advantage of computational, statistical, mathematical approaches and enhances the understanding of immunological knowledge."
},
{
"id": 38,
"uri": "http://edamontology.org/topic_0080",
"label": "Sequence analysis",
"synonyms": [
"Sequences",
"Biological sequences",
"Sequence databases"
],
"description": "The archival, processing and analysis of molecular sequences (monomer composition of polymers) including molecular sequence data resources, sequence sites, alignments, motifs and profiles."
},
{
"id": 39,
"uri": "http://edamontology.org/topic_0097",
"label": "Nucleic acid structure analysis",
"synonyms": [
"DNA structure",
"Nucleic acid structure",
"Nucleic acid denaturation",
"DNA melting",
"RNA structure alignment",
"RNA structure",
"Nucleic acid thermodynamics",
"RNA alignment"
],
"description": "The archival, curation, processing and analysis of nucleic acid structural information, such as whole structures, structural features and alignments, and associated annotation."
},
{
"id": 40,
"uri": "http://edamontology.org/topic_0654",
"label": "DNA",
"synonyms": [
"Ancient DNA",
"DNA analysis",
"Chromosomes"
],
"description": "DNA sequences and structure, including processes such as methylation and replication."
}
]
}