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"uri": "http://edamontology.org/topic_3325",
"label": "Rare diseases",
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"Rare_disease"
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"description": "The study of rare diseases."
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"id": 112,
"uri": "http://edamontology.org/topic_3420",
"label": "Reproductive health",
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"Family planning",
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"Fertility medicine"
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"description": "The health of the reproductive processes, functions and systems at all stages of life."
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"id": 118,
"uri": "http://edamontology.org/topic_0099",
"label": "RNA",
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"Small RNA"
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"id": 108,
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"label": "RNAi experiment",
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"description": "RNAi experiments."
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"id": 13,
"uri": "http://edamontology.org/topic_3170",
"label": "RNA-Seq",
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"RNA sequencing",
"RNA-Seq analysis",
"Whole transcriptome shotgun sequencing",
"WTSS",
"Small-Seq",
"Small RNA sequencing",
"Small RNA-Seq",
"miRNA-seq",
"MicroRNA sequencing",
"Transcriptome profiling"
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"description": "A topic concerning high-throughput sequencing of cDNA to measure the RNA content (transcriptome) of a sample, for example, to investigate how different alleles of a gene are expressed, detect post-transcriptional mutations or identify gene fusions."
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{
"id": 92,
"uri": "http://edamontology.org/topic_3320",
"label": "RNA splicing",
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"Splice sites"
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"description": "RNA splicing; post-transcription RNA modification involving the removal of introns and joining of exons."
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"id": 38,
"uri": "http://edamontology.org/topic_0080",
"label": "Sequence analysis",
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"Sequences",
"Biological sequences",
"Sequence databases"
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"description": "The archival, processing and analysis of molecular sequences (monomer composition of polymers) including molecular sequence data resources, sequence sites, alignments, motifs and profiles."
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"id": 22,
"uri": "http://edamontology.org/topic_0196",
"label": "Sequence assembly",
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"Assembly"
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"uri": "http://edamontology.org/topic_0157",
"label": "Sequence composition, complexity and repeats",
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"Sequence complexity",
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"Repeat sequences",
"Sequence composition",
"Sequence repeats",
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"description": "The archival, processing and analysis of the basic character composition of molecular sequences, for example character or word frequency, ambiguity, complexity, particularly regions of low complexity, and repeats or the repetitive nature of molecular sequences."
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{
"id": 35,
"uri": "http://edamontology.org/topic_0160",
"label": "Sequence sites, features and motifs",
"synonyms": [
"Sequence profiles",
"Sequence sites",
"Sequence motifs",
"HMMs",
"Functional sites",
"Sequence features"
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"description": "The archival, detection, prediction and analysis of positional features such as functional and other key sites, in molecular sequences and the conserved patterns (motifs, profiles etc.) that may be used to describe them."
},
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"id": 23,
"uri": "http://edamontology.org/topic_3168",
"label": "Sequencing",
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"Panels",
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"DNA-Seq",
"High-throughput sequencing",
"Chromosome walking",
"Next generation sequencing",
"NGS data analysis",
"Next gen sequencing",
"High throughput sequencing",
"Targeted next-generation sequencing panels",
"NGS",
"Sanger sequencing",
"Clone verification",
"DNase-Seq"
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"description": "The determination of complete (typically nucleotide) sequences, including those of genomes (full genome sequencing, de novo sequencing and resequencing), amplicons and transcriptomes."
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"uri": "http://edamontology.org/topic_0154",
"label": "Small molecules",
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"Peptides",
"Drug structures",
"Metabolite structures",
"Amino acids",
"Toxins",
"Targets",
"Chemical structures",
"Target structures"
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"description": "Small molecules of biological significance, typically archival, curation, processing and analysis of structural information."
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"id": 107,
"uri": "http://edamontology.org/topic_3372",
"label": "Software engineering",
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"Computer programming",
"Algorithms",
"Software development",
"Data structures",
"Programming languages"
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"description": "The process that leads from an original formulation of a computing problem to executable programs."
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{
"id": 14,
"uri": "http://edamontology.org/topic_2269",
"label": "Statistics and probability",
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"Biostatistics",
"Multivariate statistics",
"Bayesian methods",
"Gaussian processes",
"Probability",
"Markov processes",
"Probabilistic graphical model",
"Inferential statistics",
"Descriptive statistics",
"Statistics"
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"description": "The application of statistical methods to biological problems."
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"id": 33,
"uri": "http://edamontology.org/topic_1317",
"label": "Structural biology",
"synonyms": [
"Structural determination",
"Structural assignment",
"Structure determination"
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"description": "The molecular structure of biological molecules, particularly macromolecules such as proteins and nucleic acids."
},
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"id": 28,
"uri": "http://edamontology.org/topic_0081",
"label": "Structure analysis",
"synonyms": [
"Structural bioinformatics",
"Computational structural biology",
"Structure data resources",
"Molecular structure",
"Structures",
"Structure databases",
"Biomolecular structure"
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"description": "The curation, processing, analysis and prediction of data about the structure of biological molecules, typically proteins and nucleic acids and other macromolecules."
},
{
"id": 104,
"uri": "http://edamontology.org/topic_0082",
"label": "Structure prediction",
"synonyms": [
"Nucleic acid design",
"Nucleic acid folding",
"RNA structure prediction",
"Protein structure prediction",
"Nucleic acid structure prediction",
"DNA structure prediction",
"Protein fold recognition"
],
"description": "The prediction of molecular structure, including the prediction, modelling, recognition or design of protein secondary or tertiary structure or other structural features, and the folding of nucleic acid molecules and the prediction or design of nucleic acid (typically RNA) sequences with specific conformations."
},
{
"id": 79,
"uri": "http://edamontology.org/topic_2259",
"label": "Systems biology",
"synonyms": [
"Biological system modelling",
"Systems modelling",
"Biological modelling"
],
"description": "The holistic modelling and analysis of complex biological systems and the interactions therein."
},
{
"id": 9,
"uri": "http://edamontology.org/topic_0637",
"label": "Taxonomy",
"synonyms": null,
"description": "Organism classification, identification and naming."
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{
"id": 120,
"uri": "http://edamontology.org/topic_2840",
"label": "Toxicology",
"synonyms": [
"Toxicoinformatics",
"Computational toxicology"
],
"description": "Toxins and the adverse effects of these chemical substances on living organisms."
}
]
}